What is the Difference Between Amlodipine and Lercanidipine?
🆚 Go to Comparative Table 🆚Amlodipine and lercanidipine are both antihypertensive drugs belonging to the dihydropyridine class of calcium channel blockers. They are used to treat high blood pressure and have a similar mechanism of action. However, there are some differences between the two medications:
- Efficacy: Both amlodipine and lercanidipine have been found to be effective in reducing blood pressure in hypertensive patients. However, some studies suggest that lercanidipine may have a slightly superior effect in terms of blood pressure reduction compared to amlodipine.
- Tolerability: Lercanidipine has been associated with a lower incidence of vasodilation-related side effects, particularly pedal edema (swelling of the feet), compared to amlodipine. In a study comparing the two drugs, amlodipine patients had significantly higher rates of edema (19%) and early study discontinuations due to edema (8.5%) compared to lercanidipine.
- Adverse Events: Both drugs can cause adverse events, but the incidence of peripheral edema, a common side effect, is lower with lercanidipine (9%) compared to amlodipine (19%). This difference in tolerability may potentially enhance treatment outcomes by promoting better adherence to therapy.
In conclusion, both amlodipine and lercanidipine are effective antihypertensive drugs with a similar mechanism of action. However, lercanidipine has been associated with a lower incidence of vasodilation-related side effects, particularly pedal edema, compared to amlodipine.
Comparative Table: Amlodipine vs Lercanidipine
Amlodipine and lercanidipine are both calcium channel blockers (CCBs) used to treat hypertension, but they have some differences in their effects on the body. Here is a table comparing the two medications:
Feature | Amlodipine | Lercanidipine |
---|---|---|
Oedema-forming potential | Greater than lercanidipine | Lower than amlodipine |
Blood pressure reduction | Similar decrease in both drugs | Similar decrease in both drugs |
Efficacy | Equal efficacy in reducing blood pressure | Equal efficacy in reducing blood pressure |
Tolerability | May cause adverse effects such as pedal edema | Associated with fewer adverse effects |
Pharmacological action | L-type calcium channel blocker | N-type and L-type calcium channel blocker |
Amlodipine is a prototype dihydropyridine CCB, while lercanidipine is a newer dihydropyridine compound with lipophilic properties. Both drugs have similar efficacy in reducing blood pressure. However, the oedema-forming potential of amlodipine is greater than that induced by lercanidipine. Additionally, lercanidipine is associated with fewer adverse effects compared to amlodipine. For patients who develop adverse effects as a result of using other CCBs, lercanidipine may be a better choice.
- Nifedipine vs Amlodipine
- Amlodipine vs Amlodipine Besylate
- Telmisartan vs Amlodipine
- Dihydropyridine vs Nondihydropyridine Calcium Channel Blockers
- Lidocaine vs Lignocaine
- Dibucaine vs Lidocaine
- Lidocaine vs Benzocaine
- Atenolol vs Metoprolol
- Ace Inhibitors vs Angiotensin Receptor Blockers
- Clopidogrel Bisulfate vs Clopidogrel Hydrogen Sulfate
- Viagra vs Levitra
- Lactam vs Lactim
- Cetirizine vs Loratadine
- Metoprolol Tartrate vs Metoprolol Succinate
- Lenalidomide vs Thalidomide
- Aceclofenac vs Diclofenac
- L Carnitine vs Acetyl L Carnitine
- Clonazepam vs Lorazepam
- Lidocaine vs Septocaine