What is the Difference Between Cholinergic and Anticholinergic?

The main difference between cholinergic and anticholinergic drugs lies in their effects on the parasympathetic nervous system and the neurotransmitter acetylcholine. Here are the key differences:

• Cholinergic drugs stimulate the activation of the parasympathetic nervous system by activating receptors for acetylcholine. They increase the production of acetylcholine, which helps muscles contract and plays a role in various bodily functions, such as cognitive functions, pupil constriction, salivary, lacrimal, and bronchial secretions, smooth muscle stimulation, and urination.
• Anticholinergic drugs inhibit the parasympathetic nervous system by blocking the action of acetylcholine, so that it cannot bind to receptors that initiate the parasympathetic response. They work by inhibiting cholinergic receptors and diminishing the action of acetylcholine.

In summary, cholinergic drugs enhance the action of acetylcholine and stimulate the parasympathetic nervous system, while anticholinergic drugs block the action of acetylcholine and inhibit the parasympathetic nervous system.

Comparative Table: Cholinergic vs Anticholinergic

Cholinergic and anticholinergic drugs are pharmacological agents that act on the parasympathetic nervous system, which is responsible for relaxation and rest. Here is a table comparing the differences between cholinergic and anticholinergic drugs:

Cholinergic drugs work by increasing acetylcholine levels, promoting muscle contraction and relaxation. They stimulate the parasympathetic nervous system, which is responsible for rest and digestion. Examples of cholinergic drugs include Bethanechol (Urecholine), Pilocarpine (Pilocar), Neostigmine (Prostigmin), and Donepezil (Aricept).

On the other hand, anticholinergic drugs block acetylcholine receptors or prevent the release of acetylcholine, reducing parasympathetic actions and increasing sympathetic ones. They inhibit the parasympathetic nervous system, which can lead to reduced secretions, increased heart rate, and altered mental status. Examples of anticholinergic drugs include Atropine, Ipratropium, Scopolamine, Benztropine, Oxybutynin, and Solifenacin succinate.