What is the Difference Between Co and Post Translational Modification?
🆚 Go to Comparative Table 🆚The main difference between co- and post-translational modifications lies in the timing of these protein modifications.
Co-translational modifications occur during the translation process, while the polypeptide chains are still being synthesized. These modifications mainly take place in the rough endoplasmic reticulum (RER) and include processes such as regulation of translation, protein folding and processing, myristoylation, prenylation, and palmitoylation.
Post-translational modifications, on the other hand, occur after the translation process is complete. These modifications can take place in various cellular compartments, including the Golgi apparatus, endosomes, lysosomes, and secretory vesicles. Examples of post-translational modifications include phosphorylation, glycosylation, ubiquitination, nitrosylation, methylation, acetylation, lipidation, and proteolysis.
In summary, the key difference between co- and post-translational modifications is the timing of these processes, with co-translational modifications occurring during translation and post-translational modifications occurring after translation.
Comparative Table: Co vs Post Translational Modification
Co- and post-translational modifications are two types of protein modifications that occur during and after translation. Here is a table comparing the differences between them:
Feature | Co-translational Modification | Post-translational Modification |
---|---|---|
Definition | Occurs during protein synthesis. | Occurs after protein synthesis is completed. |
Location | Mainly takes place in the rough endoplasmic reticulum (RER). | Takes place in the Golgi, endosomes, lysosomes, and secretory vesicles. |
Examples | Regulation of translation, protein folding and processing, myristoylation, prenylation, and palmitoylation. | Phosphorylation, glycosylation, ubiquitination, nitrosylation, methylation, acetylation, lipidation, and proteolysis. |
Both co- and post-translational modifications are structural modifications that take place during and after translation. They play crucial roles in various biological processes and contribute to the complexity of the proteome.
- Post Transcriptional vs Post Translational Modification
- Transcriptional vs Posttranscriptional Gene Silencing
- Allosteric vs Covalent Modulation
- CO vs Co
- Ubiquitination vs SUMOylation
- Prosthetic Group vs Coenzyme
- Transamination vs Deamination
- Glycosylation vs Glycosidation
- Transcription vs Translation
- Transformation vs Transduction
- Phosphorylation vs Dephosphorylation
- Transition vs Transversion
- Cis vs Trans Isomers
- Aminoacyl tRNA vs Peptidyl tRNA
- Cis vs Trans Face of Golgi Apparatus
- Transformation vs Transfection
- Proteomics vs Transcriptomics
- Transformation vs Transmutation
- Transposon vs Retrotransposon