What is the Difference Between DCIS and Invasive Ductal Carcinoma?
🆚 Go to Comparative Table 🆚The main difference between ductal carcinoma in situ (DCIS) and invasive ductal carcinoma (IDC) lies in the extent of the cancer's spread within the breast.
- DCIS is a pre-cancerous condition where cancer cells are present in the milk ducts but have not invaded the surrounding breast tissue. It is considered a non-invasive lesion and is considered the obligate precursor of invasive ductal carcinoma. Approximately 14%-53% of untreated DCIS cases will naturally progress to IDC.
- IDC is a type of breast cancer that starts in the cells lining the milk ducts and has invaded the surrounding breast tissue. IDC accounts for about 80% of all invasive breast cancers in women and is the most common type of breast cancer, making up nearly 70-80% of all breast cancer diagnoses.
Some other differences between DCIS and IDC include:
- Symptoms: DCIS usually has no symptoms and is often diagnosed through mammograms, while IDC may present with symptoms such as a lump, changes in breast shape, or skin changes.
- Diagnosis: About 80% of DCIS cases are found through mammograms, which appear as shadowy areas. IDC is also often detected through mammograms, but it may also be found during routine physical exams or when symptoms are present.
- Treatment: The treatment for DCIS and IDC is different, as DCIS is a pre-cancerous condition, while IDC is an invasive cancer. Treatment options for IDC depend on the size and location of the tumor, the patient's healing capacity, and personal preferences.
- Prognosis: DCIS is considered a pre-cancerous condition and has a better prognosis compared to IDC, which is an invasive cancer with the potential to spread to other parts of the body.
On this pageWhat is the Difference Between DCIS and Invasive Ductal Carcinoma? Comparative Table: DCIS vs Invasive Ductal Carcinoma
Comparative Table: DCIS vs Invasive Ductal Carcinoma
Here is a table comparing the differences between Ductal Carcinoma in Situ (DCIS) and Invasive Ductal Carcinoma (IDC):
Feature | DCIS | IDC |
---|---|---|
Definition | DCIS is a non-invasive mammary carcinoma that has not yet broken through the ductal basement membrane. | IDC is an invasive breast cancer that has broken through the ductal basement membrane and can spread to other parts of the body. |
Prevalence | DCIS accounts for approximately 20% of mammographically detected breast cancers. | IDC is a more advanced form of breast cancer and accounts for a significant portion of breast cancer cases. |
Progression | Approximately 14%-53% of untreated DCIS cases will naturally progress to IDC. | IDC is an invasive form of breast cancer and has a higher potential for spreading to other parts of the body. |
Tumor Size | The average diameter of DCIS is 2.1±1.7 cm. | The average diameter of IDC is 2.5±1.5 cm. |
Comedonecrosis | The proportion of comedonecrosis is 10.8% in DCIS. | The proportion of comedonecrosis is 3.7% in IDC. |
Molecular Differences | DCIS is genetically advanced, showing a similar degree and position of chromosomal alterations as invasive ductal cancer. | IDC has more advanced molecular changes and is considered a more aggressive form of breast cancer. |
It is important to note that some studies have found no significant difference in copy number changes between DCIS and IDC, suggesting that further research is needed to better understand the molecular differences between these two types of breast cancer.
Read more:
- Invasive vs Non Invasive Breast Cancer
- Dysplasia vs Carcinoma In Situ
- Breast Cancer vs Fibroadenoma
- Carcinoma vs Melanoma
- Invasion vs Metastasis
- Adenoma vs Adenocarcinoma
- Verrucous Carcinoma vs Squamous Cell Carcinoma
- Intestinal vs Diffuse Gastric Cancer
- Adenocarcinoma vs Squamous Cell Carcinoma
- Stage 2 vs Stage 3 Breast Cancer
- Basal Cell Carcinoma vs Squamous Cell Carcinoma
- Thymoma vs Thymic Carcinoma
- Hepatocellular Carcinoma vs Cholangiocarcinoma
- Keratoacanthoma vs Squamous Cell Carcinoma
- Squamous Cell Carcinoma vs Adenocarcinoma Cervix
- Multifocal vs Multicentric Breast Cancer
- Ulcer vs Cancer
- Screening Mammogram vs Diagnostic Mammogram
- Cervical vs Ovarian Cancer