What is the Difference Between Helix-Loop-Helix and Helix-Turn-Helix?
🆚 Go to Comparative Table 🆚The key difference between helix-loop-helix (HLH) and helix-turn-helix (HTH) lies in their functions and structures:
- Helix-Loop-Helix (HLH):
- Mediates protein dimerization.
- Mainly consists of alpha-helices joined by a loop.
- Contains certain proto-oncogenes and genes involved in differentiation encoding transcription.
- Helix-Turn-Helix (HTH):
- Regulates gene expression through DNA binding.
- Consists of loops joined by a short amino acid strand forming a groove.
- Each monomer is organized with two α-helices, joined by a short amino acid strand, and binds to a groove in the DNA helix.
In summary, HLH is involved in protein dimerization and consists of alpha-helices joined by a loop, while HTH regulates gene expression through DNA binding and consists of loops joined by a short amino acid strand forming a groove.
On this pageWhat is the Difference Between Helix-Loop-Helix and Helix-Turn-Helix? Comparative Table: Helix-Loop-Helix vs Helix-Turn-Helix
Comparative Table: Helix-Loop-Helix vs Helix-Turn-Helix
The main differences between Helix-Loop-Helix (HLH) and Helix-Turn-Helix (HTH) are their functions and structures. Here is a table summarizing the key differences:
Feature | Helix-Loop-Helix (HLH) | Helix-Turn-Helix (HTH) |
---|---|---|
Function | Dimerization of proteins | Regulation of gene expression through DNA binding |
Structure | Mainly consists of α-helices joined by a loop | Mainly consists of loops joined by a short amino acid stand forming a groove |
Motifs | Contains proto-oncogenes and genes involved in differentiation encoding transcription factors | Formed by a right-handed three helical bundle with helices α2 and α3 arranged perpendicular to one another |
Both HLH and HTH are protein structural motifs, and they share a common denominator in basal and specific transcription factors. They are present in eukaryotes.
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