What is the Difference Between Methylcobalamin and Hydroxocobalamin?

Methylcobalamin and hydroxocobalamin are both natural and active forms of vitamin B12, but they have some differences in their structures and functions.

Methylcobalamin:

• It is the most bioavailable type of vitamin B12, meaning the body absorbs it more easily.
• Naturally occurring, it is found in animal-based foods such as meat, fish, milk, and eggs.
• It is the most active form of vitamin B12 and is mainly used in the liver, brain, and nervous system.
• Methylcobalamin is considered superior to cyanocobalamin, as it is readily available for use by the cells.

Hydroxocobalamin:

• It contains a hydroxyl group instead of the methyl or cyano group of methylcobalamin and cyanocobalamin.
• Helps reduce the unwanted amount of nitric oxide in the body, which, if not removed, can lead to a range of diseases.
• Compared to cyanocobalamin, hydroxocobalamin helps detoxify the excess cyanide produced from smoking and polluted air, protecting against the ill effects of free radicals and oxidative stress.
• Hydroxocobalamin can work hand in hand with glutathione to help fight against autoimmune diseases.
• It is a precursor of methylcobalamin and adenosylcobalamin, the two bioactive coenzyme forms of vitamin B12.
• Hydroxocobalamin is retained in the blood for longer than synthetic forms of B12 (cyanocobalamin).

While there is no consensus among health practitioners as to which type of vitamin B12 is the most effective, the best type is the one that works best for the individual. Both methylcobalamin and hydroxocobalamin have benefits, and they can be used together for optimal results.

Comparative Table: Methylcobalamin vs Hydroxocobalamin

Here is a table comparing the differences between methylcobalamin and hydroxocobalamin:

In summary, methylcobalamin is a naturally occurring, highly bioavailable form of vitamin B12, while hydroxocobalamin is a man-made injectable form of vitamin B12. Both forms can be synthesized in the laboratory and are available in pharmacies. They can be taken orally or through injections to treat vitamin B12 deficiency and are important for individuals with MTHFR genetic mutations.