What is the Difference Between Motif and Domain?
🆚 Go to Comparative Table 🆚The main difference between a motif and a domain in protein structure is that a motif is a super secondary structure, while a domain is a tertiary structure of the protein. Here are the key differences between motifs and domains:
- Type of Structure: A motif is a super secondary structure made up of connectivity between secondary structural pieces, such as alpha helices and beta sheets. A domain, on the other hand, is a three-dimensional protein structure with independent folding.
- Formation: Motifs are formed by connected alpha helices and beta sheets through loops, while domains are formed by the formation of disulfide bridges, ionic bonds, and hydrogen bonds between amino acid side chains.
- Significance: Motifs mainly have a structural function in the protein structure and have similar functions through protein families. Domains, however, have functional importance and unique functions in the protein structure.
- Stability: Motifs are not independently stable, while domains are independently stable.
In summary, motifs are super secondary structures with connectivity between secondary structural pieces, and they mainly have a structural function in protein families. Domains, on the other hand, are independently stable, three-dimensional structures with unique functions in the protein structure.
Comparative Table: Motif vs Domain
Here is a table summarizing the differences between motifs and domains in proteins:
Feature | Motif | Domain |
---|---|---|
Definition | A motif is a certain grouping of super secondary elements of proteins, such as alpha helices and beta-strands, that form a recognizable pattern in different proteins. | A domain is an independently stable structure of a protein, containing a hydrophobic core built from secondary structural units. |
Independence | Motifs are not independently stable. | Domains are independently stable. |
Function | Motifs do not typically depict the function of a protein. | Domains often depict the function of a protein. |
Structure | Motifs are small regions of protein three-dimensional structure or amino acid sequence. | Domains are larger, independently folded regions with specific functions. |
In summary, motifs are short, functional sequences within a protein, while domains are larger, independently folded regions with specific functions. Motifs are not independently stable, whereas domains are.
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