What is the Difference Between Myositis and Rhabdomyolysis?
🆚 Go to Comparative Table 🆚Myositis and rhabdomyolysis are both related to muscle damage and dysfunction, but they differ in their underlying causes, symptoms, and consequences:
Myositis:
- Inflammation of muscle tissue, usually caused by viral infections, autoimmune disorders, or medication side effects.
- Common triggers include influenza A/B, enteroviruses, Epstein-Barr virus, and others.
- Symptoms include muscle pain, weakness, and sometimes fever and fatigue.
- Creatine kinase levels are only mildly elevated.
- Influenza myositis usually resolves spontaneously within 6 weeks.
Rhabdomyolysis:
- Rapid death of muscle tissue, resulting from injury, drug toxicity, disease, or other causes.
- Causes include viral infections, trauma, myotoxic substances, autoimmune myositis, and medication side effects.
- Symptoms include muscle pain (particularly in the shoulders, thighs, or lower back), muscle weakness, and dark red or brown urine (the color of tea) or decreased urine production.
- Creatine kinase levels are markedly elevated, sometimes greater than 5,000 u/l.
- Rhabdomyolysis can lead to acute kidney injury (AKI) and, in rare cases, death if not promptly treated.
In some cases, patients experiencing severe, acute-onset myositis may develop rhabdomyolysis as a complication. Early diagnosis and treatment of both conditions are crucial for successful outcomes.
On this pageWhat is the Difference Between Myositis and Rhabdomyolysis? Comparative Table: Myositis vs Rhabdomyolysis
Comparative Table: Myositis vs Rhabdomyolysis
Here is a table comparing the differences between myositis and rhabdomyolysis:
Feature | Myositis | Rhabdomyolysis |
---|---|---|
Definition | Myositis is a condition that causes inflammation of the muscle. | Rhabdomyolysis is a condition that causes muscle breakdown and muscle death. |
Causes | Myositis can be caused by various factors, including infections, autoimmune disorders, and certain medications. | Rhabdomyolysis is often caused by drug or alcohol abuse, medicinal drug use, trauma, Neuroleptic Malignant Syndrome (NMS), and immobility. |
Symptoms | Symptoms of myositis may include muscle pain, stiffness, and weakness. | Symptoms of rhabdomyolysis include myalgia, weakness, and myoglobinuria, with an elevation in creatine kinase (CK) level being the most sensitive test for muscle injury-induced rhabdomyolysis. |
Diagnosis | Diagnosis of myositis typically involves a thorough medical history, physical examination, and laboratory tests, such as blood tests and imaging studies. | Diagnosis of rhabdomyolysis is based on the presence of muscle injury with an unexpected rise in serum CK levels, as well as clinical manifestations. |
Treatment | Treatment for myositis depends on the underlying cause and may include rest, physical therapy, medications, and in some cases, surgery. | Treatment for rhabdomyolysis involves addressing the underlying cause, managing complications, and supporting the affected patient, as well as preventing further muscle damage. |
Complications | Untreated myositis can lead to muscle atrophy, contractures, and chronic pain. | Untreated rhabdomyolysis can lead to acute kidney injury, hyperkalemia, and disseminated intravascular coagulation. |
Remember that both myositis and rhabdomyolysis can lead to life-threatening complications if not treated in a timely manner.
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