Author
Home > Health > What is the Difference Between NAC and Glutathione?

Guilherme Mazui

•4 minutes to read

What is the Difference Between NAC and Glutathione?

🆚 Go to Comparative Table 🆚

N-acetyl-cysteine (NAC) and glutathione are both antioxidants that play important roles in the body, but they have different functions and sources.

NAC:

  • NAC is a derivative of the amino acid L-cysteine, which is sulfur-based.
  • It is popular due to its cysteine residues and its role in glutathione maintenance and metabolism.
  • NAC is known to have a significant impact on glutathione levels, resulting in a 26.3% increase in time to exhaustion at 92% peak VO2 in a study.
  • Normal dosing recommendations for NAC range from 600 mg to 1800 mg daily.

Glutathione:

  • Glutathione is an antioxidant that is naturally produced by the body and is considered one of the most vital antioxidants.
  • It plays a crucial role in minimizing lipid peroxidation of cellular membranes and other targets that occur with oxidative stress.
  • Glutathione is available in various forms, such as reduced glutathione (100 mg to 200 mg daily) and liposomal glutathione softgel (250 mg to 500 mg daily).

Both NAC and glutathione have multiple benefits for health, and NAC is known to promote the production of glutathione in the body. However, each individual may react differently to these supplements, and it is essential to consult a healthcare provider before starting any new supplement regimen.

On this page
  • What is the Difference Between NAC and Glutathione?
  • Comparative Table: NAC vs Glutathione

    • Comparative Table: NAC vs Glutathione

    Here is a table comparing the differences between N-acetylcysteine (NAC) and glutathione:

    Feature NAC Glutathione
    Description NAC is a form of acetylcysteine and comes from the amino acid L-cysteine. Glutathione is an antioxidant compound that exists in plants, animals, fungi, bacteria, and some archaea.
    Function NAC serves as a precursor for glutathione, providing the building blocks for the body to create its own glutathione. Glutathione functions as a cellular antioxidant and is involved in various metabolic reactions, including the biosynthesis of leukotrienes and prostaglandins.
    Bioavailability NAC is thought to have a higher bioavailability than standard oral glutathione formulas, as it bypasses the liver and isn't subjected to further metabolism. Glutathione can be administered in various ways, such as orally, topically, intravenously, intranasally, or via a nebulizer. However, research suggests that intravenous administration may be more effective than oral administration.
    Stability NAC seems to be more stable than glutathione. Glutathione is less stable than NAC.
    Side Effects Some people may experience diarrhea, nausea, vomiting, and skin rashes when taking NAC. Glutathione supplementation is generally well-tolerated.
    Converted to Glutathione NAC is a precursor of cysteine and glutathione, and administering NAC increases cysteine levels in the body, which in turn boosts glutathione levels. Glutathione is not converted to NAC.

    In summary, NAC is a precursor for glutathione and provides the building blocks for the body to create its own glutathione, while glutathione is an antioxidant compound involved in various cellular functions. NAC bypasses the liver and has a higher bioavailability than standard oral glutathione formulas, but some people may experience side effects when taking NAC. On the other hand, glutathione is generally well-tolerated but may be less stable than NAC.

    Read more:

    Guilherme Mazui

    Guilherme Mazui is graduated in journalism from the Federal University of Minas Gerais (UFMG) and a master's degree in Communication from the University of São Paulo (USP). In addition, he has experience in advertising writing and has worked as a content editor in several companies.