What is the Difference Between Neuroblastoma and Medulloblastoma?
🆚 Go to Comparative Table 🆚Neuroblastoma and medulloblastoma are two different types of pediatric brain tumors that share some similarities but also have distinct differences. Here are the main differences between them:
- Origin: Neuroblastoma is a cancer of immature nerve cells that typically starts outside of the brain, usually in the nerve tissue near the upper spine, chest, abdomen, or pelvis. Medulloblastoma, on the other hand, is a brain cancer that starts in the lower back part of the brain called the cerebellum.
- Metastasis: Medulloblastomas primarily metastasize within the central nervous system (CNS), while neuroblastomas mainly metastasize to lymph nodes, bone, bone marrow, and, in infants, also spread to the liver and subcutaneous tissue.
- Histology: There is more heterogeneity in the underlying neuroblastoma pathology, including a higher stromal component. Medulloblastoma, however, is distinguished by elevated PC, glycine, and scylloinositol, markers of increased cell proliferation.
- Inheritance: Neuroblastoma can be inherited, but medulloblastoma is not inherited.
These two tumors are both connected to the nervous system, are types of embryonal tumors, and are common in children. They have similar treatment regimens, such as surgery and radiation, and are both rare in adults.
On this pageWhat is the Difference Between Neuroblastoma and Medulloblastoma? Comparative Table: Neuroblastoma vs Medulloblastoma
Comparative Table: Neuroblastoma vs Medulloblastoma
Here is a table comparing the differences between neuroblastoma and medulloblastoma:
Feature | Neuroblastoma | Medulloblastoma |
---|---|---|
Origin | Nerve tissue near the upper spine, chest, abdomen, or pelvis | Lower back part of the brain (cerebellum) |
Derived from | Early neuron cells called neuroblasts in the sympathetic nervous system | Undeveloped neurons in the cerebellum |
Age of occurrence | Mostly in infants and young children, but rare in children older than 10 years | Typically in children with a median age of 9 years, and a peak in incidence between the ages of 3 and 7 years |
Inheritance | Can be inherited | Not inherited |
Location | Malignant embryonal tumor of the peripheral nervous system | Malignant embryonal tumor of the central nervous system |
Overall Survival Rate | Varies depending on molecular genetic subgroup, from less than 45% to over 95% | Approximately 75% |
Please note that the above table is based on the provided search results, which offer a concise summary of the differences between these two types of pediatric tumors.
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