What is the Difference Between Protein C and Protein S Deficiency?
🆚 Go to Comparative Table 🆚Protein C and Protein S are vitamin K-dependent glycoproteins that play essential roles in regulating blood coagulation as natural anticoagulants. Deficiencies in these proteins can lead to an increased risk of venous thromboembolism and, in some cases, arterial diseases. Congenital protein C or S deficiency is an inherited disorder passed down through families, with protein C deficiency occurring in about 1 in 300 people and protein S deficiency being much less common, affecting about 1 in 20,000 people.
The main differences between protein C and protein S deficiency include:
- Inheritance: Protein C deficiency is more common and can be inherited in an autosomal dominant manner, while protein S deficiency is less common and may be acquired or inherited.
- Symptoms: Both deficiencies can lead to abnormal blood clotting, but the symptoms may vary depending on the specific type of deficiency. For example, type III protein S deficiency is characterized by normal total protein S levels but low free protein S levels and low protein S activity.
- Diagnosis: Laboratory tests are used to measure the levels of proteins C and S in the blood, and separate tests for protein C and S are often performed at the same time.
Treatment for both deficiencies often involves blood-thinning drugs to prevent and treat blood clots. Additionally, patients with these conditions should be cautious to prevent clots from forming, especially during periods of prolonged bed rest or other situations that may cause blood to move slowly in the veins.
Comparative Table: Protein C vs Protein S Deficiency
Protein C and Protein S are vitamin K-dependent glycoproteins that play essential roles in the regulation of blood coagulation as natural anticoagulants. Deficiencies in these proteins can lead to an increased risk of venous thromboembolism. Here is a table summarizing the differences between Protein C and Protein S deficiency:
| Protein C Deficiency | Protein S Deficiency |
|---|---|
| Type 1: Related to insufficient quantity | Free form of PS is an important cofactor for APC |
| Heterozygous gene mutation in 1 out of 200-500 people | Heterozygous gene mutation in 1 out of 500 people |
| APC resistance not associated with protein S deficiency | APC resistance not associated with protein C deficiency |
| Higher risk for arterial thrombosis in subjects with protein C deficiency | Higher risk for arterial thrombosis in subjects with protein S deficiency |
| Acquired deficiencies more prevalent (up to 4% in control subjects) | Acquired deficiencies more prevalent (up to 4% in control subjects) |
Both Protein C and Protein S deficiencies are inherited in an autosomal dominant pattern. While Protein C and Protein S deficiencies share some similarities, they also have distinct differences in their association with thrombotic risks and the presence of acquired deficiencies.
- Protein A vs Protein G
- Cysteine vs Selenocysteine
- Protein Kinase A vs Protein Kinase C
- Proteinase K vs Protease
- C-reactive Protein vs Creatinine
- Protease vs Proteinase
- Protein vs Creatine
- Soya Protein vs Whey Protein
- Complete vs Incomplete Proteins
- Enzyme vs Protein
- Fibrin vs Fibrinogen
- Vitamin B12 vs Folic Acid Deficiency
- Cysteine vs Serine
- Whey Protein vs Protein
- Simple Protein vs Conjugated Protein
- Anemia vs Iron Deficiency
- Thrombin vs Prothrombin
- Hemophilia A vs B vs C
- Hemolytic Anemia vs Iron Deficiency Anemia