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Guilherme Mazui

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What is the Difference Between Vasculogenesis and Angiogenesis?

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Vasculogenesis and angiogenesis are both processes involved in the formation of blood vessels, but they differ in their mechanisms and temporal occurrence:

  • Vasculogenesis refers to the in situ differentiation and growth of blood vessels from mesodermal angiogenesis involves two distinct mechanisms: endothelial sprouting and intussusceptive microvascular growth (IMG).
  • Endothelial sprouting is based on endothelial cell migration, proliferation, and tube formation.
  • IMG divides existing vessel lumens by forming and inserting tissue folds and columns.

Vasculogenesis is mainly observed during embryonic development, while angiogenesis can occur in adults during the healing of injured tissues, organ growth, or pregnancy.

In summary, vasculogenesis is the formation of new blood vessels from mesodermal angiogenesis is the sprouting and remodeling of new blood vessels from existing ones.

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  • What is the Difference Between Vasculogenesis and Angiogenesis?
  • Comparative Table: Vasculogenesis vs Angiogenesis

    • Comparative Table: Vasculogenesis vs Angiogenesis

    Here is a table comparing vasculogenesis and angiogenesis:

    Feature Vasculogenesis Angiogenesis
    Definition The formation of new blood vessels from primordial endothelial stem cells or angioblasts The formation of new blood vessels from pre-existing capillary structures
    Occurrence During embryonic development and in adults with heart and brain damage In response to injury, tissue damage, or tumor growth
    Process Involves the growth and differentiation of cells called angioblasts into endothelial cells Involves the sprouting or intussusceptive growth of endothelial cells from pre-existing blood vessels
    Role in Cancer Invasive tumor cells can mimic vasculogenesis to form new blood vessels for tumor growth Tumors can stimulate angiogenesis to develop a new blood supply for their growth and development

    In summary, vasculogenesis is the process of forming new blood vessels from endothelial stem cells or angioblasts, typically occurring during embryonic development and in certain adult situations. Angiogenesis, on the other hand, is the formation of new blood vessels from pre-existing ones, often in response to injury or diseases such as cancer.

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    Guilherme Mazui

    Guilherme Mazui is graduated in journalism from the Federal University of Minas Gerais (UFMG) and a master's degree in Communication from the University of São Paulo (USP). In addition, he has experience in advertising writing and has worked as a content editor in several companies.